This research focuses on exploring the biophysical factors controlling vascular architecture, remodeling, and integration upon implantation. Using cutting edge methods to pattern the organization of cells, and to map and control mechanical forces within the 3D constructs, the role of cell-generated forces, initial endothelial cell organization and external mechanical forces in the location, orientation and extent of sprouting is studied. In addition, the impact of hierarchical network geometry, rationally designed, on implant integration in-vivo is assessed.
This research is supported by United States-Israel BSF grant in collaboration with Prof. Christopher Chen from Boston University.